Program Thursday  05.09.2019

 

09:00-10:15

Registration and Coffee

10:15-10:30

WELCOME

Fabio Grassi and Massimiliano Fontana, Presidents SSAI 2019

10:30-11:30

PLENARY OPENING SESSION

Chairs: Fabio Grassi (Bellinzona, CH) / Massimiliano Fontana (Mendrisio, CH)

Spontaneous protein crystallization as a driver of immunity
Bart Lambrecht, University of Ghent, Belgium

The extended phenotype and immunopathology of human RAG deficiency
Luigi Notarangelo, National Institute of Allergy and Infectious Diseases, Bethesda, USA

 

11:30-12:45

SYMPOSIUM 1: BASIC IMMUNOLOGY
"SELF /NON-SELF RECOGNITION AND SIGNALLING"

Chairs: Greta Guarda (Bellinzona, CH) / Christian Münz (Zurich, CH)

Inflammasomes at the Crossroads of Innate and Cell-autonomous immunity
Petr Broz, University of Lausanne, Switzerland

Breath of fresh AIRE
Jakub Abramson, Weizmann Institute of Science, Rehovot, Israel

Recognition strategies of innate lymphoid cells
Chiara Romagnani, German Rheumatism Research Centre, Berlin, Germany

 

 

SYMPOSIUM 2: CLINICAL IMMUNOLOGY
"IMMUNITY AND IMMUNOTHERAPY"

Chairs: Daniel Legler (Kreuzlingen, CH) / Burkhard Ludewig (St. Gallen,CH)

Tregs and self tolerance
Jonathan Sprent, Garvan Institute for Medical Research, Sydney, Australia

Learning from self and not self human memory repertoire
Elisabetta Traggiai, Novartis, Basel, Switzerland

Innate lymphocytes: new avenues in immunotherapy?
Camilla Jandus, University of Lausanne, Switzerland

 

 

SYMPOSIUM 3: ALLERGOLOGY
"IMMUNOREGULATION OF ALLERGY"

Chairs: Peter Schmid-Grendelmeier (Zurich, CH) / Martin Bachmann (Bern, CH)

Novel B cell subsets and regulation of allergic inflammation
Mübeccel Akdis, Swiss Institute of Allergy and Asthma Research, Davos, Switzerland

Therapeutic targeting of IgE in allergic disease
Alexander Eggel, University of Bern, Switzerland

Novel insights into the allergic late-phase reaction
Barbara Bohle, Medical University of Vienna, Austria

 

12:45-14:15

Lunch break in Exhibit Hall

13:15-14:15

Poster viewing at the Villa Ciani

INDUSTRY-SPONSORED SYMPOSIUM S1 – GlaxoSmithKline AG

The Eosinophil journey from research to the clinical praxis: Eosinophils from research to clinical treatment of asthma and EGPA
Hans-Uwe Simon, Bern, Switzerland / Oliver Hausmann, Zurich, Switzerland / Marcus Kühn, Zurich, Switzerland

INDUSTRY-SPONSORED SYMPOSIUM S2 – Takeda

HAE treatment - the next generation !
Urs Steiner, Zurich, Switzerland / Markus Magerl, Berlin, Germany

INDUSTRY-SPONSORED SYMPOSIUM S3 – A. MENARINI AG (30 MIN.) (FLYER)

Approach and managment of urticaria in 2019
State of the art diagnostis & management - special aspects in childhood - future therapeutic options
Peter Schmid-Grendelmeier, Zurich, Switzerland


14:15 - 15:30

SYMPOSIUM 4:  BASIC IMMUNOLOGY
"IMMUNITY AT MUCOSAL SITES"

Chairs: Silvia Monticelli (Bellinzona, CH) / Santiago Gonzalez (Bellinzona, CH)

Intestinal barrier and microbiota in the gut-liver-brain axis
Maria Rescigno, Humanitas University, Milan, Italy

Tissue-specific features of human innate lymphoid cells
Jenny Mjösberg, Karolinska Institute, Stockholm, Sweden

Mediators of allergic airway inflammation
Manfred Kopf, ETH Zurich, Switzerland

 

 

SYMPOSIUM 5:  LABORATORY DIAGNOSTICS

Chairs: Franco Keller (Bellinzona, CH) / Ingmar Heijnen (Basel, CH)

Pemphigoid and Pemphigus, two organ-specific autoimmune bullous diseases: features and diagnostic approach
Luca Borradori, Bern University Hospital, Switzerland

Laboratory diagnostics
Diego Vergani, King's College Hospital, London, UK

Clinical Flow Cytometry: Beyond Routine Immunophenotyping
Michaela Fux, Bern University Hospital, Switzerland

 

 

SYMPOSIUM 6:  JOINT SSAI / EADV DERMATOLOGY
"FROM INFLAMMATION TO TISSUE REGENERATION"

Chairs: Michel Gilliet (Lausanne, CH) / Marcel Bergmann (Bellinzona, CH)

The bright and the dark sides of fibroblast growth factors in skin immunology
Sabine Werner, ETH, Zurich, Switzerland

Th2 cell subsets
Christoph Schlapbach, Bern University Hospital, Switzerland

Dissociating inflammation from fibrosis in systemic sclerosis
Carlo Chizzolini, Geneva University Hospital, Switzerland

15:30-16:00

Coffee break in Exhibit Hall

16:00-17:00

WORKSHOP: BASIC IMMUNOLOGY

Chairs: Nicole Joller (Zurich, CH) / Stéphanie Hugues (Geneva, CH)

BI-1 Tissue-Resident group 2 innate lymphoid cells differentiate by layered ontogeny and in situ perinatal priming
Christoph Schneider, Institute of Physiology / University of Zurich, Switzerland

BI-2 MR1T cells recognising self-antigens are adaptive-like T cells
Alessandro Vacchini, Department Biomedicine, University and University Hospital Basel, Switzerland

BI-3 CD36-PPAR? signaling supports metabolic adaptation of Tregs for survival and functional fitness in tumors
Wang Haiping, Ludwig Cancer Research Institute Lausanne Branch, Department of Fundamental Oncology, University of Lausanne, Switzerland

BI-4 The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer
Philippe Krebs, Institute of Pathology, University of Bern, Switzerland

BI-5 A single T cell epitope drives the neutralizing anti-idiotypic antibody response to natalizumab in patients with multiple sclerosis
Luca Piccoli, Institute for Research in Biomedicine, Bellinzona, Switzerland



WORKSHOP: ALLERGOLOGY AND CLINICAL IMMUNOLOGY

Chairs: Mübeccel Akdis (Davos, CH) / Louis-François Debétaz (Lausanne, CH)

AC-1 Single cell mass cytometry multiparametric immunophenotyping of peripheral blood cells in systemic lupus erythematosus
Morgane Humbel, Department of Immunology and Allergy, University Hospital and University of Lausanne, Switzerland

AC-2 Urticaria is frequent in hypersensitivity reactions to intravenous iron infusions
Esther Steveling-Klein, Division of Allergy, University Hospital Basel, Switzerland

AC-3 Apremilast in treatment-refractory recurrent aphthous stomatitis
Antonios Kolios, Department of Immunology, University Hospital Zurich, Switzerland

AC-4 Establishment of a specialised clinic for mastocytosis patients at the University of Basel
Zita-Rose Manjaly Thomas, Basel, Switzerland

 

 

MEET THE EXPERT 1

“TOLERANCE AND TRANSPLANTATION"

Chair: Massimiliano Fontana (Mendrisio, CH)

Julien Vionnet, King's College Hospital, London, UK

 

MEET THE EXPERT 2
“NEW THERAPIES IN ATOPIC DERMATITIS"

Chair: Giovanni Ferrari (Bellinzona, CH)

Stephan Weidinger, University Hospital Schleswig-Holstein, Kiel, Germany

 

 

17:15-18:30

SSAI GENERAL ASSEMBLY

18:30-19:30

RECEPTION AT THE PALAZZO DEI CONGRESSI

20.00-22:30

CONGRESS DINNER AT THE LAC

 

 

Program Friday  06.09.2019

 

07:30 - 08:30

Registration

08:30 - 09:30

Plenary Session 1  Joint SSAI and SFI

Chairs: Doron Merkler (Geneva, CH) / Thomas Hauser (Zurich, CH)

 

Immune landscape of rhabdoid tumors: non-genetic mechanisms of tumor immunogenicity
Eliane Piaggio, Institute Curie, Paris, France

Human inborn errors of IL-17-mediated immunity
Anne Puel, INSERM - Institute Imagine, Paris, France

09:30 - 10:00

Coffee break in Exhibit Hall

10:00 - 11:30

Symposium 7: Basic Immunology
"EFFECTORS IN AUTOIMMUNITY"

Chairs: Mike Recher (Basel, CH) / Marcus Thelen (Bellinzona, CH)

Heterologous immunity and the impact of infection history on inflammatory diseases
Nicole Joller, University of Zurich, Switzerland

The vast and plastic world of effector T helper lymphocytes
Francesco Annunziato, University of Florence, Italy

The T cell myeloid interface: cytokine control of phagocytes
Burkhard Becher, University of Zurich, Switzerland

 

Symposium 8: Allergology
"PATHOGENESIS AND THERAPIES"

Chairs: Peter Jandus (Geneva, CH) / Nathalie Jeannet-Peter (Geneva, CH)

Nucleic-acid driven inflammation of the skin
Michel Gilliet, Lausanne University Hospital, Switzerland

The skin microbiome in atopic dermatitis
Martin Glatz, Clinic for Skin, Allergy and Immunsystem, Uster, Switzerland

Vaccination against peanut allergy using virus-like particles
Martin Bachmann, University of Bern, Switzerland

 

Symposium 9: Laboratory Diagnostics

Chairs: Alan Valaperti (Zurich, CH) / Lionel Arlettaz (Sion, CH)

Oral Presentations from Abstracts

LD-1 Case report: IgE monoclonal gammopathy
Dehilia Chevalley
, Divison of Immunology and Allergology, CHUV, Lausanne, Switzerland

LD-2 Analysis of B-cell subpopulations by flow cytometry for diagnosing immunodeficiency: Differences between laboratories in Switzerland.
Michaela Fux,
University Hospital Basel, University of Basel, Basel, Switzerland

LD-3 Clinical implications of nucleolar staining of antinuclear antibodies
David Spoerl,
Geneva University Hospital, Geneva, Switzerland

LD-4 Are antibodies against La (SSB) no longer useful for the diagnosis of Sjögren’s syndrome?
David Spoerl,
Geneva University Hospital, Geneva, Switzerland

11:45 - 12:45

Plenary Session 2

Chairs: Fabio Grassi (Bellinzona, CH) / Antonio Lanzavechhia (Bellinzona, CH)

Therapeutic plasticity of neural stem cells
Gianvito Martino, San Raffaele Hospital, Milan, Italy

Infection and immune control of human oncogenic gamma-herpesviruses in vivo
Christian Münz, University of Zurich, Switzerland

12:45-14:15

Lunch break in Exhibit Hall

13:15 - 14:15

Poster viewing at the Villa Ciani

INDUSTRY-SPONSORED SYMPOSIUM S4 - Sanofi Genzyme

Dupixent (Dupilumab)-Innovative Approach for the Management of Atopic Dermatitis
Martin Glatz, Uster, Switzerland / Carlo Mainetti, Bellinzona, Switzerland / Andrea Azzola, Luzern, Switzerland

INDUSTRY-SPONSORED SYMPOSIUM S5 - Stallergenes Greer

Real World Evidence of pollen Immunotherapy efficacy
Peter Eng, Aarau/Lucerne, Switzerland / Pascal Demoly, Montpellier, France

INDUSTRY-SPONSORED SYMPOSIUM S6 - Novartis Pharma Schweiz AG

Inhibition of IL-1B as a therapeutic strategy in periodic fever syndromes
Carlo Chizzolini, Geneva, Switzerland / Michael Hofer, Lausanne, Switzerland

 

14:15 - 15:30

 

Symposium 10: Basic Immunology
EFIS / ACTERIA

Chairs: Anne Hosmalin (Paris, F) / Federica Sallusto (Bellinzona, CH)

Innate DNA sensing mechanisms
Andrea Ablasser, EPFL, Lausanne, Switzerland

An NK cell-driven inflammatory switch regulated by cyclooxygenase-2 activity restricts tumor growth and predicts cancer patient outcome
Eduardo Bonavita, Cancer Research UK Manchester Institute, UK

Tissue-specific factors in lung immunity
Samuel Philip Nobs, Weizmann Institute of Science, Rehovot, Israel

Reconstructing the human immune system using single cells technologies
Muzlifah Haniffa, Newcastle University, UK

 

Symposium 11: Clinical Immunology
"ONCOIMMUNOLOGY"

Chairs: Andrea Alimonti (Bellinzona, CH) / Roger Geiger (Bellinzona, CH)

Accessories to the crime: Functions of immune cells in the tumour microenvironment
Arianna Calcinotto,
Institute for Oncology Research (IOR), Bellinzona

Clinical potential of TCR-ligand avidity in cancer and infectious diseases
Nathalie Rufer, University Hospital Lausanne, Switzerland

Dendritic cells beyond antigen presentation
David Sancho, Spanish National Center for Cardiovascular Research, Madrid, Spain

 

Symposium 12: Aerobiology
"AIR POLLUTION AND THE IMMUNE SYSTEM"
(Co-Sponsored: SSAI and SSA)

Chairs: Pierre Gumowski (Geneva, CH) / Massimiliano Fontana (Bellinzona, CH)

Size-resolved endotoxin and oxidative potential of atmospheric particles
Jing Wang, EMPA, Dübendorf, Switzerland

Hazard assessment of inhaled particulate matter – clinical aspects and experimental designs to study immune effects
Barbara Rothen, Adolphe Merkle Institute, Fribourg, Switzerland

TBD

15:30 - 16:00

Coffee break in Exhibit Hall

16:00 - 16:15

Poster Awards

16:15 - 17:15

PLENARY SESSION 3
JOINT WITH VIRAL IMMUNITY SYMPOSIUM

Chair: Daniel Speiser (Lausanne, CH)

T cell differentiation with an asymmetric perspective
Annette Oxenius, ETH, Zurich, Switzerland

The power of clonal selection
Antonio Lanzavecchia, IRB, Università della Svizzera italiana, Bellinzona, Switzerland

17:15 - 17:30

CLOSING REMARKS

Fabio Grassi and Massimiliano Fontana, Presidents SSAI 2019

 

 

Program Saturday  07.09.2019

VIRAL IMMUNITY SYMPOSIUM / UNIVERSITA DELLA SVIZZERA ITALIANA

 

08:00 - 09:00

Registration

 

09:00-10:30

SYMPOSIUM
"IMMUNITY IN THE LIVER"

Chair: Benedette Terziroli Beretta-Piccoli (Lugano, CH)

Spatiotemporal dynamics and genomic landscape of CD8+ T cells undergoing intrahepatic priming
Matteo Iannacone, San Raffaele Scientific Institute, Milan, Italy

Hepatitis B hijacks the tolerogenic liver niche
Mala Maini, University College London, UK

Passive antibody therapies against endemic, emerging and re-emerging infectious diseases
Davide Corti, Humabs BioMed, Bellinzona, Switzerland

10:30-11:00

Coffee break

11:00 - 12:30

SYMPOSIUM
ADAPTIVE IMMUNITY IN VIRAL INFECTIONS"

Chair: Giandomenica Iezzi (Bellinzona, CH)

Humoral immune defense in chronic viral infection
Daniel Pinschewer, University of Basel, Switzerland

Zika virus, pregnancy and antibodies
Davide F. Robbiani, Rockefeller University, New Yor, USA

Deciphering CD4+ T cell immunodominance to Influenza virus
Antonino Cassotta
, Institute for Research in Biomedicine, Università della
Svizzera italiana, Bellinzona, Switzerland

Chronic immune activation as a cause of poor T helper cell migration in successfully ART treated HIV-1 infected individuals
Valentina Cecchinato, Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland

12:30 -14.00

Lunch break

14.00 - 15.00

SYMPOSIUM 
"INNATE IMMUNITY IN VIRAL INFECTIONS"

Chair: Luca Varani (Bellinzona, CH)

Immune recognition of murine leukemia virus
Stefan Bauer, Philipps University of Marburg, Germany

Organization of the innate immune response and disturbance by viruses
Andreas Pichlmair, Technical University Munich, Germany

 

15:00 - 15:30

Coffee break

15:30-16:30

CLOSING LECTURE

Chair: Fedrica Sallusto (Bellinzona, CH)

MHC-E, a new player in T cell immunity
Andrew McMichael, University of Oxford, UK

16:30 - 16:45

Closing Remarks

Federica Sallusto (Bellinzona, CH)